IISER Kolkata Webinar on “Membrane Cholesterol and the Serotonin1A Receptor: Recent Insights from Structural Biology”
Overview:
Department of Biological Sciences, IISER Kolkata is organizing a “Membrane Cholesterol and the Serotonin1A Receptor: Recent Insights from Structural Biology”.
Seminar Host:
Prof. Jayasri Das Sarma
Date and Time:
4 PM, 23 June 2021
How to Apply:
Participants are open to attending the webinar by registering through the below-given link.
Abstract:
G protein-coupled receptors (GPCRs) are the largest molecules involved in signal transduction across membranes and represent major drug targets in all clinical areas.
The serotonin1A receptor is an important neurotransmitter receptor of the GPCR superfamily and is implicated in the generation and modulation of various cognitive, behavioral, and developmental functions. Our earlier work demonstrated that membrane cholesterol is necessary for ligand binding, G-protein coupling, and signaling of serotonin1A receptors.
In the overall context of high-resolution structures of GPCRs showing bound cholesterol molecules, we previously reported the presence of cholesterol recognition/interaction amino acid consensus (CRAC) motifs in the serotonin1A receptor.